Effects of immunosuppression on the efficacy of vaccination against Mycoplasma gallisepticum infection in chickens

Immunosuppression can increase the susceptibility of chickens to other disease-causing pathogens and interfere with efficacy vaccination against those pathogens. Chicken anaemia virus (CAV) infectious bursal disease (IBDV) are common causes immunosuppression in chickens. was induced by experimental infection either CAV or IBDV assess effect on Mycoplasma gallisepticum strain ts-304 virulent M. gallisepticum, a bacterial pathogen worldwide. Birds were experimentally infected at 1 week age, before challenge examine time vaccination, 6 weeks after but investigate challenge. All birds vaccinated single dose vaccine 3 age challenged Ap3AS 8 age. In immunosuppressed there reduction protection offered two challenge, as measured tracheal mucosal thicknesses, serum antibody levels air sac lesion scores load trachea. Immunosuppressed detectable antibodies less likely have lesions. This study has shown that caused mycoplasmosis